Best San Francisco 49ers fantasy performances last season
Every season in the NFL produces performances that feel less like a single game and more like statistical outliers — explosive outings where quarterbacks pile up passing yards, running backs break off long scoring runs, and receivers turn routine targets into multi-touchdown afternoons. These are the kinds of games that separate good fantasy weeks from historic ones.
Stacker compiled a ranking of the best San Francisco 49ers fantasy performances in 2025 using data from Stathead. The list includes the highest single-game fantasy scores by quarterbacks, running backs, wide receivers, and tight ends. Players are ranked based on standard fantasy scoring.
Best quarterback fantasy games
#10. Brock Purdy, January 11, 2026
– Stats: 262 Passing Yards, 2 Passing TDs, 2 Interceptions, 24 Rushing Yards
– Game: SFO vs PHI, 23-19 Win
– Fantasy points: 16.88
#9. Brock Purdy, November 30, 2025
– Stats: 168 Passing Yards, 1 Passing TDs, 0 Interceptions, 1 Rushing TDs
– Game: SFO vs CLE, 26-8 Win
– Fantasy points: 17.12
#8. Brock Purdy, September 28, 2025
– Stats: 309 Passing Yards, 2 Passing TDs, 2 Interceptions, 13 Rushing Yards
– Game: SFO vs JAX, 21-26 Loss
– Fantasy points: 17.66
#7. Mac Jones, October 26, 2025
– Stats: 193 Passing Yards, 2 Passing TDs, 1 Interceptions, 23 Rushing Yards
– Game: SFO vs HOU, 15-26 Loss
– Fantasy points: 18.02
#6. Mac Jones, September 14, 2025
– Stats: 279 Passing Yards, 3 Passing TDs, 0 Interceptions
– Game: SFO vs NOR, 26-21 Win
– Fantasy points: 21.76
#5. Mac Jones, October 2, 2025
– Stats: 342 Passing Yards, 2 Passing TDs, 0 Interceptions
– Game: SFO vs LAR, 26-23 (OT) Win
– Fantasy points: 22.18
#4. Mac Jones, November 9, 2025
– Stats: 319 Passing Yards, 3 Passing TDs, 1 Interceptions
– Game: SFO vs LAR, 26-42 Loss
– Fantasy points: 23.06
#3. Brock Purdy, December 14, 2025
– Stats: 295 Passing Yards, 3 Passing TDs, 0 Interceptions, 44 Rushing Yards
– Game: SFO vs TEN, 37-24 Win
– Fantasy points: 26.2
#2. Brock Purdy, December 22, 2025
– Stats: 295 Passing Yards, 5 Passing TDs, 1 Interceptions, 11 Rushing Yards
– Game: SFO vs IND, 48-27 Win
– Fantasy points: 30.9
#1. Brock Purdy, December 28, 2025
– Stats: 303 Passing Yards, 3 Passing TDs, 1 Interceptions, 28 Rushing Yards, 2 Rushing TDs
– Game: SFO vs CHI, 42-38 Win
– Fantasy points: 36.92
Best running back fantasy games
#10. Christian McCaffrey, October 12, 2025
– Stats: 54 Rushing Yards, 1 Rushing TDs, 57 Receiving Yards
– Game: SFO vs TAM, 19-30 Loss
– Fantasy points: 17.1
#9. Christian McCaffrey, October 2, 2025
– Stats: 57 Rushing Yards, 0 Rushing TDs, 82 Receiving Yards, 1 Receiving TDs
– Game: SFO vs LAR, 26-23 (OT) Win
– Fantasy points: 19.9
#8. Christian McCaffrey, September 28, 2025
– Stats: 49 Rushing Yards, 0 Rushing TDs, 92 Receiving Yards, 1 Receiving TDs
– Game: SFO vs JAX, 21-26 Loss
– Fantasy points: 20.1
#7. Christian McCaffrey, November 24, 2025
– Stats: 89 Rushing Yards, 1 Rushing TDs, 53 Receiving Yards
– Game: SFO vs CAR, 20-9 Win
– Fantasy points: 20.2
#6. Christian McCaffrey, January 11, 2026
– Stats: 48 Rushing Yards, 0 Rushing TDs, 66 Receiving Yards, 2 Receiving TDs
– Game: SFO vs PHI, 23-19 Win
– Fantasy points: 23.4
#5. Christian McCaffrey, December 28, 2025
– Stats: 140 Rushing Yards, 1 Rushing TDs, 41 Receiving Yards
– Game: SFO vs CHI, 42-38 Win
– Fantasy points: 24.1
#4. Christian McCaffrey, December 22, 2025
– Stats: 117 Rushing Yards, 0 Rushing TDs, 29 Receiving Yards, 2 Receiving TDs
– Game: SFO vs IND, 48-27 Win
– Fantasy points: 26.6
#3. Christian McCaffrey, November 2, 2025
– Stats: 106 Rushing Yards, 1 Rushing TDs, 67 Receiving Yards, 1 Receiving TDs
– Game: SFO vs NYG, 34-24 Win
– Fantasy points: 29.3
#2. Christian McCaffrey, November 16, 2025
– Stats: 81 Rushing Yards, 2 Rushing TDs, 40 Receiving Yards, 1 Receiving TDs
– Game: SFO vs ARI, 41-22 Win
– Fantasy points: 30.1
#1. Christian McCaffrey, October 19, 2025
– Stats: 129 Rushing Yards, 2 Rushing TDs, 72 Receiving Yards
– Game: SFO vs ATL, 20-10 Win
– Fantasy points: 32.1
Best wide receiver fantasy games
#10. Jauan Jennings, December 28, 2025
– Stats: 42 Receiving Yards, 1 Receiving TDs, 2 Receptions, 4 Targets
– Game: SFO vs CHI, 42-38 Win
– Fantasy points: 10.2
#9. Ricky Pearsall, September 7, 2025
– Stats: 108 Receiving Yards, 0 Receiving TDs, 4 Receptions, 7 Targets
– Game: SFO vs SEA, 17-13 Win
– Fantasy points: 10.8
#8. Jauan Jennings, November 9, 2025
– Stats: 71 Receiving Yards, 1 Receiving TDs, 6 Receptions, 9 Targets
– Game: SFO vs LAR, 26-42 Loss
– Fantasy points: 11.1
#7. Ricky Pearsall, September 21, 2025
– Stats: 117 Receiving Yards, 0 Receiving TDs, 8 Receptions, 11 Targets
– Game: SFO vs ARI, 16-15 Win
– Fantasy points: 11.7
#6. Jauan Jennings, December 22, 2025
– Stats: 71 Receiving Yards, 1 Receiving TDs, 5 Receptions, 6 Targets
– Game: SFO vs IND, 48-27 Win
– Fantasy points: 13.1
#5. Kendrick Bourne, October 12, 2025
– Stats: 142 Receiving Yards, 0 Receiving TDs, 5 Receptions, 9 Targets
– Game: SFO vs TAM, 19-30 Loss
– Fantasy points: 14.2
#4. Kendrick Bourne, October 2, 2025
– Stats: 142 Receiving Yards, 0 Receiving TDs, 10 Receptions, 11 Targets
– Game: SFO vs LAR, 26-23 (OT) Win
– Fantasy points: 14.2
#3. Jauan Jennings, September 14, 2025
– Stats: 89 Receiving Yards, 1 Receiving TDs, 5 Receptions, 10 Targets
– Game: SFO vs NOR, 26-21 Win
– Fantasy points: 14.9
#2. Jauan Jennings, December 14, 2025
– Stats: 37 Receiving Yards, 2 Receiving TDs, 3 Receptions, 5 Targets
– Game: SFO vs TEN, 37-24 Win
– Fantasy points: 15.7
#1. Demarcus Robinson, January 11, 2026
– Stats: 111 Receiving Yards, 1 Receiving TDs, 6 Receptions, 7 Targets
– Game: SFO vs PHI, 23-19 Win
– Fantasy points: 17.1
Best tight end fantasy games
#10. George Kittle, November 24, 2025
– Stats: 78 Receiving Yards, 0 Receiving TDs, 6 Receptions, 10 Targets
– Game: SFO vs CAR, 20-9 Win
– Fantasy points: 7.8
#9. George Kittle, September 7, 2025
– Stats: 25 Receiving Yards, 1 Receiving TDs, 4 Receptions, 4 Targets
– Game: SFO vs SEA, 17-13 Win
– Fantasy points: 8.5
#8. Jake Tonges, October 2, 2025
– Stats: 41 Receiving Yards, 1 Receiving TDs, 7 Receptions, 11 Targets
– Game: SFO vs LAR, 26-23 (OT) Win
– Fantasy points: 10.1
#7. George Kittle, October 26, 2025
– Stats: 43 Receiving Yards, 1 Receiving TDs, 4 Receptions, 5 Targets
– Game: SFO vs HOU, 15-26 Loss
– Fantasy points: 10.3
#6. Jake Tonges, September 28, 2025
– Stats: 58 Receiving Yards, 1 Receiving TDs, 3 Receptions, 5 Targets
– Game: SFO vs JAX, 21-26 Loss
– Fantasy points: 11.8
#5. Jake Tonges, December 28, 2025
– Stats: 60 Receiving Yards, 1 Receiving TDs, 7 Receptions, 9 Targets
– Game: SFO vs CHI, 42-38 Win
– Fantasy points: 12.0
#4. George Kittle, November 9, 2025
– Stats: 84 Receiving Yards, 1 Receiving TDs, 9 Receptions, 9 Targets
– Game: SFO vs LAR, 26-42 Loss
– Fantasy points: 14.4
#3. George Kittle, December 14, 2025
– Stats: 88 Receiving Yards, 1 Receiving TDs, 8 Receptions, 9 Targets
– Game: SFO vs TEN, 37-24 Win
– Fantasy points: 14.8
#2. George Kittle, December 22, 2025
– Stats: 115 Receiving Yards, 1 Receiving TDs, 7 Receptions, 8 Targets
– Game: SFO vs IND, 48-27 Win
– Fantasy points: 17.5
#1. George Kittle, November 16, 2025
– Stats: 67 Receiving Yards, 2 Receiving TDs, 6 Receptions, 6 Targets
– Game: SFO vs ARI, 41-22 Win
– Fantasy points: 18.7
